George,
If you are asking if you need to install addtional software on your computer to run a usb device the answer is generally no.
Most of the usb interfaces that are available configure as a joystick. Windows has built in drivers, HID or Human Interface Device, and will automatically install when the usb device is plugged in.
Once it is configured then FMS will see a joystick so just set FMS up for jostick input and away you go.
Dennis
:p